Plant natural products are chemicals of great pharmaceutical significance due to their structural complexity and chemical diversity. However, discovery and manufacturing of plant natural products have lagged behind those of microbial natural products primarily due to the size and complexity of plant genomes and the difficulty in plant biosynthetic pathway prediction and engineering. Our research goal is to develop metabolic engineering and synthetic biology platforms that enable the systematic discovery and production of plant natural products and their derivatives, ultimately transforming our ability to understand how nature achieves complex compound biosynthesis.